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PATIENTS ARE MISSING OUT ON OPTIMAL ASTHMA CONTROL

Despite available treatments, many patients remain uncontrolled.
Type 2 inflammation is a common pathology of both allergic and eosinophilic asthma phenotypes, impacting many patients with poorly controlled asthma.1-4

  • HIGHLY PREVALENT
    Type 2 inflammation occurs in ~50%a to 70%b of adult patients with asthma1,2
    a N=205.
    b N=37.
  • HETEROGENEOUS AND COMPLEX
    Type 2 inflammation in asthma is found in both allergic and eosinophilic phenotypes, and in many patients not clearly defined by either3,4
  • BEYOND EXACERBATION REDUCTION
    Optimal asthma management should aim to reduce OCS use and improve lung function—which is directly correlated to risk of future exacerbations and poor asthma control5,6
EXPLORE TYPE 2 INFLAMMATION BUILD YOUR OWN PATIENT OCS, oral corticosteroids. REFERENCES
  1. Seys SF, Scheers H, Van den Brande P, et al. Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients. Respir Res. 2017;18(1):39. doi:10.1186/s12931-017-0524-y
  2. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133(2):388-394.
  3. Robinson D, Humbert M, Buhl R, et al. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161-175.
  4. Wenzel SE. Emergence of biomolecular pathways to define novel asthma phenotypes: type-2 immunity and beyond. Am J Respir Cell Mol Biol. 2016;55(1):1-4.
  5. Nguyen VQ, Ulrik CS. Measures to reduce maintenance therapy with oral corticosteroid in adults with severe asthma. Allergy Asthma Proc. 2016;37(6):125-139.
  6. Global Initiative for Asthma. 2018 GINA Report, Global Strategy for Asthma Management and Prevention. http://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention/. Accessed June 11, 2018.